John W.P. Toole, MD, FRCPC

Toole Dermatology Research
203 and 205 Edmonton Street
Winnipeg, Manitoba, Canada
R3C 1R4


Specialty: Dermatology


Research Interests: Acne, Actinic Keratoses, Basal Cell Carcinoma, Dermatitis, Drying Skin, Psoriasis, Rosacea, Seborrheic Dermatitis, Skin Cancer

Dr. John Toole is a Board Certified Dermatologist. He has been practicing Dermatology in Winnipeg, Manitoba since 1981 and in 1989, Dr. Toole started conducting clinical trials. Since then, he has conducted over 123 clinical trials in dermatology, for indications including psoriasis, acne, onychomycosis, rosacea and dermatitis.

Dr. Toole is the member of numerous committees including the Canadian Association of Professors of Dermatology, Royal College of Physicians and Surgeons of Canada, American Academy of Dermatology, Canadian Dermatology Association, and the European Academy of Dermatology.

Dr. Toole is dedicated to teaching his profession. His current positions include the Head of the Section of Dermatology and Professor of Medicine in the Department of Medicine, and Associate Professor in the Department of Pediatrics at the University of Manitoba. Dr. Toole is also the Dermatologist-in-Chief at the Winnipeg Regional Health Authority. 


Click to view Dr. John Toole's Publications

Kuzyk A, Silver S, Wallace S, Hamza S, Toole J. A case indistinguishable between indeterminate cell histiocytosis and cutaneous Rosai-Dorfman disease. J Cutan Med Surg 2016 Aug 9. [Epub ahead of print]. PMID: 27507795

Asai Y, Tan J, Baibergenova A, Barankin B, Cochrane CL, Humphrey S, Lynde CW, Marcoux D, Poulin Y, Rivers JK, Sapijaszko M, Sibbald RG, Toole J, Zip C. Canadian Clinical Practice Guidelines for Rosacea. J Cutan Med Surg 2016 May 17. [Epub ahead of print]. PMID: 27207355

Asai Y, Baibergenova A, Dutil M, Humphrey S, Hull P, Lynde C, Poulin Y, Shear NH, Tan J, Toole J, Zip C. Management of acne: Canadian clinical practice guideline. CMAJ 2016 Feb 2; 188(2): 118-26. Epub 2015 Nov 16. PMID: 26573753 / doi: 10.1503/cmaj.140665

Kalb RE, Fiorentino DF, Lebwohl MG, Toole J, Poulin Y, Cohen AD, Goyal K, Fakharzadeh S, Calabro S, Chevrier M, Langholff W, You Y, Leonardi CL. Risk of serious infection with biologic and systemic treatment of psoriasis: results from the psoriasis longitudinal assessment and registry (PSOLAR). JAMA Dermatol 2015 Sep 1; 151(9): 961-9. PMID: 25970800 / doi:10.1001/jamadermatol.2015.0718

Papp KA, Barber K, Bissonnette R, Bourcier M, Lynde CW, Poulin Y, Shelton J, Garces K, Toole J, Poulin-Costello M. Improvements in patient-reported outcomes in patients with psoriasis receiving etanercept plus topical therapies: results from REFINE. J Eur Acad Dermatol Venereol 2015 Aug; 29(8): 1555-61. Epub 2015 Jan 21. PMID: 25611084 / doi: 10.1111/jdv.12934

Papp KA, Barber K, Bissonnette R, Bourcier M, Lynde CW, Poulin Y, Shelton J, Toole J, Vieria A, Poulin-Costello M. A Randomized, blinded assessor study to Evaluate the efficacy and safety of etanercept 50 mg once weekly plus as Needed topical agent vs etanercept 50 mg twice weekly in patients with moderate to severe plaque psoriasis (REFINE). J Eur Acad Dermatol Venereol 2015 Feb; 29(2): 361-6. Epub 2014 Jul 1. PMID: 24980988 / doi: 10.1111/jdv.12555

Tan J, Humphrey S, Vender R, Barankin B, Gooderham M, Kerrouche N, Audibert F, Lynde C, POWER study group. A treatment for severe nodular acne: a randomized investigator-blinded, controlled, noninferiority trial comparing fixed-dose adapalene/benzoyl peroxide plus doxycycline vs. oral isotretinoin. Br J Dermatol 2014 Dec; 171(6): 1508-16. Epub 2014 Oct 28. PMID: 24934963 / doi: 10.1111/bjd.13191

Stein Gold L, Kircik L, Fowler J, Jackson JM, Tan J, Draelos Z, Fleischer A, Appell M, Steinhoff M, Lynde C, Sugarman J, Liu H, Jacovella J, Ivermectin Phase 3 Study Group. Long-term safety of ivermectin 1% cream vs azelaic acid 15% gel in treating inflammatory lesions of rosacea: results of two 40-week controlled, investigator-blinded trials. J Drugs Dermatol 2014 Nov; 13(11): 1380-6. PMID: 25607706

Lynde C, Tan J, Andriessen A, Barankin B, Dutil M, Gilbert M, Hong CH, Humphrey S, Rochette L, Toole J, Thomas R, Vender R, Wiseman M, Zip C. A consensus on acne management focused on specific patient features. J Cutan Med Surg 2014 Jul-Aug; 18(4): 243-55. PMID: 25008441

Lynde C, Tan J, Andriessen A, Barankin B, Dutil M, Gilbert M, Hong CH, Humphrey S, Rochette L, Toole J, Thomas R, Vender R, Wiseman M, Zip C. A consensus on acne management focused on specific patient features. J Cutan Med Surg 2014 Apr; 18: 1-13. PMID: 24713444

Lynde CW, Andriessen A, Barankin B, Gannes GD, Gulliver W, Haber R, McCuaig C, Rajan P, Skotnicki SP, Thomas R, Toole J, Vender R. Moisturizers and ceramide-containing moisturizers may offer concomitant therapy with benefits. J Clin Aesthet Dermatol 2014 Mar; 7(3): 18-26. PMID: 24688622

Wong JG, Toole J, Demers AA, Musto G, Wiseman MC. Topical 5% imiquimod in the treatment of lentigo maligna. J Cutan Med Surg 2012 Jul-Aug; 16(4):245-9. PMID: 22784516

Albrecht L, Bourcier M, Ashkenas J, Papp K, Shear N, Toole J, Vender R, Wasel N; Canadian Psoriasis Guidelines Committee. Topical psoriasis therapy in the age of biologics: evidence-based treatment recommendations. J Cutan Med Surg 2011 Nov-Dec; 15(6):309-21. PMID: 22202506

Papp K, Gulliver W, Lynde C, Poulin Y, Ashkenas J, Canadian Psoriasis Guidelines Committee. Canadian guidelines for the management of plaque psoriasis: overview. J Cutan Med Surg 2011 Jul-Aug; 15(4): 210-9. PMID: 21781627

Lynde C, Guenther L, Diepgen TL, Sasseville D, Poulin Y, Gulliver W, Agner T, Barber K, Bissonnette R, Ho V, Shear NH, Toole J. Canadian hand dermatitis management guidelines. J Cutan Med Surg 2010 Nov-Dec; 14(6): 267-84. PMID: 21084020

Canadian Psoriasis Guidelines Committee. Canadian Guidelines for the Management of Plaque Psoriasis, June 2009. 

Smylie M, Claveau J, Alanen K, Taillefer R, George R, Wong R, Mason WP, Canadian Expert Panel on Malignant Melanoma. Management of malignant melanoma: best practices. J Cutan Med Surg 2009 Mar-Apr; 13(2): 55-73. PMID: 19459245  

Vinh DC, Finlayson N, Toole J, Hamza S, Embil JM. An elderly woman with a diffuse annular eruption. Clin Infect Dis 2008; 46(10): 1581, 1624-1625. PMID: 18419493 

Kaul N, Palma KG, Silagy SS, Goodman JJ, Toole J. North American efficacy and safety of a novel pediculicide rinse, isopropyl myristate 50% (resultz). J Cutan Med Surg 2007; 11(5): 161-167. PMID: 17942025 

Toole JW. Calcipotriol and betamethasone dipropionate for the treatment of psoriasis: A 52-week study. Skin Therapy Lett 2007; 12(4): 1-3. PMID: 17551662 

Kragballe K, Austad J, Barnes L, Bibby A, de la Brassinne M, Cambazard F, Fleming C, Heikkila H, Williams Z, Peyri Rey J, Svensson A, Toole J, Wozel G. Efficacy results of a 52-week, randomized, double-blind, safety study of a calcipotriol/betamethasone dipropionate two-compound product (Daivobet®/Dovobet®/Taclonex®) in the treatment of psoriasis vulgaris. Dermatology 2006; 213(4): 319-326. PMID: 17135738 

Kragballe K, Austad J, Barnes L, Bibby A, de la Brassinne M, Cambazard F, Fleming C, Heikkila H, Jolliffe D, Peyri J, Svensson A, Toole J, Wozel G. A 52-week, randomized safety study of a calcipotriol/betamethasone dipropionate two-compound product (Dovobet/Daivobet/Taclonex) in the treatment of psoriasis vulgaris. Br J Dermatol 2006; 154(6): 1155-1160. PMID: 16704648 

Papp KA, Ho V, Langley R, Lynde C, Poulin Y, Shear N, Toole J, Zip C. Strategies for optimizing treatment with efalizumab in moderate to severe psoriasis. J Cutan Med Surg 2006; 9(Suppl 1): 26-32. PMID: 16633859 

Langley RG, Ho V, Lynde C, Papp KA, Poulin Y, Shear N, Toole J, Zip C. Recommendations for incorporating biologicals into management of moderate to severe plaque psoriasis: individualized patient approaches. J Cutan Med Surg 2006; 9(Suppl 1): 18-25. PMID: 16633860 

Lui H, Langley R, Poulin Y, Gupta AK, Carey W, Guenther L, Searles G, Toole J, Lynde C, Gulliver W, Barber K. Incorporating biologics into the treatment of psoriasis. J Cutan Med Surg 2004 Aug; 8(Suppl): 8-13. PMID: 15655584 

Gupta AK, Langley R, Poulin Y, Lui H, Searles G, Carey W, Toole J, Inniss K. Pathogenesis of psoriasis and current challenges. J Cutan Med Surg 2004 Aug; 8(Suppl): 3-7. PMID: 15655583 

Toole JW, Risk S, Finkey MB, Appa Y. Comparison of three therapeutic shampoos for the treatment of dandruff. J Am Acad Dermatol 2004 Mar; 50(3 Suppl 1): 94. 

Toole J, Silagy S, Maric A, Fath B, Quebe-Fehling E, Ibarra de Palacios P, Laurin L, Giguere M. Evaluation of irritation and sensitisation of two 50 microg/day oestrogen patches. Maturitas 2002; 43(4): 257-263. PMID: 12468134 

Wiseman MC, Orr PH, Macdonald SM, Schroeder ML, Toole JW. Actinic prurigo: clinical features and HLA associations in a Canadian Inuit population. J Am Acad Dermatol 2001; 44(6): 952-956. PMID: 11369906 

McIntosh LM, Summers R, Jackson M, Mantsch HH, Mansfield JR, Howlett M, Crowson AN, Toole JW. Towards non-invasive screening of skin lesions by near-infrared spectroscopy. J Invest Dermatol 2001; 116(1): 175-181. PMID: 11168814 

Madden WS, Landells ID, Poulin Y, Searles GE, Smith KC, Tan JK, Toole J, Zip CM, Degreef H. Treatment of acne vulgaris and prevention of acne scarring: Canadian consensus guidelines. J Cutan Med Surg 2000 Jun; 4(Suppl 1): S2-13. PMID: 11749902 

McIntosh L, Mansfield J, Crowson AN, Toole J, Mantsch H, Jackson M. Classification of infrared spectra from skin tumors. Lasers in Surgery: Advanced Characterization, Therapeutics and Systems 2000 Jan; 3907: 126-135. 

Toole JW, Lockhart L, Potrebka J, Bowman JP, Novack GD. Comparative irritancy study among retinoid creams and gels. J Cutan Med Surg 1999 Oct; 3(6): 298-301. PMID: 10575158 

Wiseman M, Magro CM, Toole J, et al. Actinic prurigo: a clinical and dermatological study of 7 Inuit and 7 Cree Indian patients. Laboratory Investigation 1998; 78: 54A. 

Oranje AP, Marcoux D, Svensson A, Prendiville J, Krafchik B, Toole J, Rosenthal D, de Waard-van der Spek FB, Molin L, Axelsen M. Topical calcipotriol in childhood psoriasis. J Am Acad Dermatol 1997 Feb; 36(2 Pt 1: 203-208. PMID: 9039169 

Ramsay C, Gilbert M, Toole J, Prendiville J, Krafchik B, Powell J, Krol A, Murray S. Optimal management of atopic dermatitis. STA Communications Inc., Copyright 1996. 

Crowson AN, Magro C, Toole J, Sheps M, Joundi M. Granulomatous mycosis fungoides. Canadian Dermatology Association Journal 1993; 7: 17-19. 

Toole J. Mechanism of action of calcipotriol in the therapy of psoriasis. The Canadian Journal of Dermatology 1993; 5(2). 

Toole J. Atopic dermatitis. Dermatology Digest 1990; 1(2). 

Thomson GT, Johnston JL, Baragar FD, Toole JW. Psoriatic arthritis and myopathy. J Rheumatol 1990 Mar; 17(3): 395-398. PMID: 2110253 

Krafchik BR, Toole JW. What is Netherton's syndrome? Int J Dermatol 1983 Oct; 22(8): 459-462. PMID: 6642830 

Toole JW, Hofstader SL, Ramsay CA. Darier's disease and Kaposi's varicelliform eruption. J Am Acad Dermatol 1979 Oct; 1(4): 321-324. PMID: 512080 

Katz A, Minto JO, Toole JW, Medwidsky W. Immunopathologic study of herpes gestationis in mother and infant. Arch Dermaotol 1977 Aug; 113(8): 1069-1072. PMID: 329771 

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